Striatal dopa and glucose metabolism in PD patients with freezing of gait
Identifieur interne : 001197 ( Main/Exploration ); précédent : 001196; suivant : 001198Striatal dopa and glucose metabolism in PD patients with freezing of gait
Auteurs : Anna L. Bartels [Pays-Bas] ; Bauke M. De Jong [Pays-Bas] ; Nir Giladi [Israël] ; Joanna D. Schaafsma [Pays-Bas] ; R. Paul Maguire [Pays-Bas] ; Lammy Veenma [Pays-Bas] ; Jan Pruim [Pays-Bas] ; Yacov Balash [Israël] ; Moussa B. H. Youdim [Israël] ; Klaus L. Leenders [Pays-Bas]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-09.
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Abstract
In Parkinson's disease (PD), freezing suggests sudden and transient blocks of motor behavior during initiating or continuous repetitive movements. Its underlying pathophysiology remains unclear. The objective of this study is to compare striatal dopamine metabolism and cerebral glucose metabolism between PD patients with and without freezing of gait (FOG). A total of 10 PD patients with FOG at off and 7 PD patients without FOG underwent brain positron emission tomography with 18[F]‐6‐fluoro‐levodopa (FDOPA) and 18[F]‐fluordesoxyglucose (FDG). Striatum decarboxylase activity was expressed by metabolic influx constants of the striatum related to the occipital lobe (Kocc). FDG uptake in caudate and putamen was normalized to global FDG uptake. Region of interest (ROI) analysis of striatal regions was used, as well as voxel‐based analysis by statistical parametric mapping (SPM). ROI analysis did not reveal differences in striatal FDOPA and FDG uptake between the groups. SPM showed lower putaminal FDOPA uptake (P = 0.05 uncorrected) with increased FDG uptake (P = 0.01 uncorrected) in freezing PD, whereas caudate uptake of the two tracers was reduced. Freezing‐related cortical FDG decrease was found in (right) parietal regions. In conclusion, in freezing PD, caudate uptake of FDG and FDOPA was reduced, whereas putamen FDOPA decrease was associated with FDG increase. Right hemisphere circuitry seemed to be more affected in freezing patients. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.20952
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H." last="Youdim">Moussa B. H. Youdim</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Eve Topf and National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases, Technion‐Faculty of Medicine, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Leenders, Klaus L" sort="Leenders, Klaus L" uniqKey="Leenders K" first="Klaus L." last="Leenders">Klaus L. Leenders</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neurology Department of the University Medical Center Groningen</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-09">2006-09</date><biblScope unit="volume">21</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1326">1326</biblScope><biblScope unit="page" to="1332">1332</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">32F8B40120EC5ECF1D85785766A13C12F5B7BD60</idno><idno type="DOI">10.1002/mds.20952</idno><idno type="ArticleID">MDS20952</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>PET</term><term>Parkinson's disease</term><term>freezing of gait</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In Parkinson's disease (PD), freezing suggests sudden and transient blocks of motor behavior during initiating or continuous repetitive movements. Its underlying pathophysiology remains unclear. The objective of this study is to compare striatal dopamine metabolism and cerebral glucose metabolism between PD patients with and without freezing of gait (FOG). A total of 10 PD patients with FOG at off and 7 PD patients without FOG underwent brain positron emission tomography with 18[F]‐6‐fluoro‐levodopa (FDOPA) and 18[F]‐fluordesoxyglucose (FDG). Striatum decarboxylase activity was expressed by metabolic influx constants of the striatum related to the occipital lobe (Kocc). FDG uptake in caudate and putamen was normalized to global FDG uptake. Region of interest (ROI) analysis of striatal regions was used, as well as voxel‐based analysis by statistical parametric mapping (SPM). ROI analysis did not reveal differences in striatal FDOPA and FDG uptake between the groups. SPM showed lower putaminal FDOPA uptake (P = 0.05 uncorrected) with increased FDG uptake (P = 0.01 uncorrected) in freezing PD, whereas caudate uptake of the two tracers was reduced. Freezing‐related cortical FDG decrease was found in (right) parietal regions. In conclusion, in freezing PD, caudate uptake of FDG and FDOPA was reduced, whereas putamen FDOPA decrease was associated with FDG increase. Right hemisphere circuitry seemed to be more affected in freezing patients. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Israël</li><li>Pays-Bas</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Bartels, Anna L" sort="Bartels, Anna L" uniqKey="Bartels A" first="Anna L." last="Bartels">Anna L. Bartels</name></noRegion><name sortKey="De Jong, Bauke M" sort="De Jong, Bauke M" uniqKey="De Jong B" first="Bauke M." last="De Jong">Bauke M. De Jong</name><name sortKey="Leenders, Klaus L" sort="Leenders, Klaus L" uniqKey="Leenders K" first="Klaus L." last="Leenders">Klaus L. Leenders</name><name sortKey="Maguire, R Paul" sort="Maguire, R Paul" uniqKey="Maguire R" first="R. Paul" last="Maguire">R. Paul Maguire</name><name sortKey="Pruim, Jan" sort="Pruim, Jan" uniqKey="Pruim J" first="Jan" last="Pruim">Jan Pruim</name><name sortKey="Schaafsma, Joanna D" sort="Schaafsma, Joanna D" uniqKey="Schaafsma J" first="Joanna D." last="Schaafsma">Joanna D. Schaafsma</name><name sortKey="Veenma, Lammy" sort="Veenma, Lammy" uniqKey="Veenma L" first="Lammy" last="Veenma">Lammy Veenma</name></country><country name="Israël"><noRegion><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name></noRegion><name sortKey="Balash, Yacov" sort="Balash, Yacov" uniqKey="Balash Y" first="Yacov" last="Balash">Yacov Balash</name><name sortKey="Youdim, Moussa B H" sort="Youdim, Moussa B H" uniqKey="Youdim M" first="Moussa B. H." last="Youdim">Moussa B. H. Youdim</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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